The burden of methicillin-resistant staphylococcus aureus infections among hospitalised patients in singapore

Authors

  • Yong Yang Department of Epidemiology, Medical Board, Singapore General Hospital, Outram Road, Singapore
  • Moi Lin Ling Infection control, Singapore General Hospital
  • Say Beng Tan Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School
  • Truls Østbye Duke-NUS Graduate Medical School
  • Arul Earnest Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-NUS Graduate Medical School
  • Han Seong Ng Medical Board, Singapore General Hospital

DOI:

https://doi.org/10.21171/ges.v13i34.2457

Abstract

Background: MRSA has caused enormous burden to affected Western patients and society. However, only limited study results originated from the Asia-Pacific populations.

Aim: To assess the burden of Methicillin-resistant S. aureus infections (MRSA) among patients from a large tertiary care hospital in Singapore.

Methods: Retrospective study using data from the hospital discharge database to identify patients with MRSA and Methicillin-sensitive S. aureus infections (MSSA) using International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Australian Modification (ICD-9-AM) codes.  

Findings: Amongst 543,068 hospitalized patients between 2004 and 2010, 8,664(1.6%) were infected with S. Aureus, including 4,868(0.9%) with MRSA. Compared with uninfected controls, MRSA patients had longer hospital stay (geometric mean, GM, 12.2 vs. 3.0 days), higher hospitalization costs (GM, $6294.7 vs. $2295.7), higher in-hospital mortality rate (7.8% vs. 2.8%) and higher 30-day all-cause unscheduled readmission rate (36.3% vs. 23.7%, all p<0.001). The difference still existed after adjustment for age groups, gender, ethnicity, medical management, and Charlson comorbidity index. Similarly, MRSA patients had longer hospital stay, higher hospitalization costs, higher in-hospital mortality rate and 30-day all-cause unscheduled readmission rate compared with patients with MSSA.

Conclusion: MRSA infection was associated with poor clinical outcomes and higher economic burden in this population. Prevention and control measures should be implemented both inside and outside the hospital setting.

Downloads

Download data is not yet available.

Downloads

Published

2018-12-01

How to Cite

Yang, Y., Lin Ling, M., Beng Tan, S., Østbye, T., Earnest, A., & Seong Ng, H. (2018). The burden of methicillin-resistant staphylococcus aureus infections among hospitalised patients in singapore. Management & Society Electronic Journal, 13(34). https://doi.org/10.21171/ges.v13i34.2457

Issue

Vol. 13 No. 34 (2019): January/April 2019

Section

Articles

License

As author of the attached article, I authorize its publication, once approved, in the Revista GES - Gestão e Sociedade. I declare that this article is of my autorship and transfer, in a free and definitive manner, the resulting property rights. I also assume full responsibility for its content.

I authorize GES - Gestão e Sociedade to publish on electronic media, on the Internet or to reproduce by other means that it may use, as well as the edition, reissue, adaptation or distribution of said article.